| Autor: |
Vasanthakumar, Vikrannth, Vikas B. R., Kiran, B. R., Bathena, Arun Kumar, Jaiswal, Deepak |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2022, Vol. 13` Issue 8, p3327-3332, 6p |
| Abstrakt: |
Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death and a major health problem worldwide. COPD is complicated by acute exacerbations that are associated with healthcare expenditures and high morbidity. Patients with severe COPD exacerbation have factors that influence serum electrolyte imbalance, such as hypoxia, respiratory acidosis, metabolic abnormalities such as serum electrolyte imbalance, uremia, and liver function abnormalities. Serum electrolyte imbalance such as hyponatremia, hypokalemia, hyperbilirubinemia, and elevated levels of transaminases, blood urea, and serum creatinine are either caused by the disease process or the therapy initiated. Objectives of this study: The objectives of this study is to estimate and compare the levels of serum electrolytes (sodium and potassium) and uric acid levels in patients with AECOPD and controls. Materials and Methods: Fasting blood samples from all the subjects were collected for the estimation of serum electrolytes like sodium and potassium and uric acid in fully automated biochemistry analyser. Results: We included a total of 80 patients (Group 1, n=40 & Group 2, n= 40) based on inclusion and exclusion criteria. We found significantly decreased levels of serum levels of sodium and potassium in patients with AECOPD compared to the controls. There was no statistically significant differences in uric acid levels between the two groups. Discussion and Conclusion: Electrolyte imbalances can cause respiratory muscle weakness and impair airway function in COPD patients. Serum sodium and potassium levels were lower in acute exacerbations of COPD who deceased during the admission, and there were no statistically significant differences in uric acid levels between the two groups. The levels of these parameters should be measured and corrected during AECOPD treatment to decrease mortality. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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