| Autor: |
Thompson, Kelsey N., Bonham, Kevin S., Ilott, Nicholas E., Britton, Graham J., Colmenero, Paula, Bullers, Samuel J., McIver, Lauren J., Ma, Siyuan, Nguyen, Long H., Filer, Andrew, Brough, India, Pearson, Claire, Moussa, Caroline, Kumar, Vinod, Lam, Lilian H., Jackson, Matthew A., Pawluk, April, Kiriakidis, Serafim, Taylor, Peter C., Wedderburn, Lucy R. |
| Předmět: |
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| Zdroj: |
Science Translational Medicine; 7/26/2023, Vol. 15 Issue 706, p1-16, 16p |
| Abstrakt: |
Musculoskeletal diseases affect up to 20% of adults worldwide. The gut microbiome has been implicated in inflammatory conditions, but large-scale metagenomic evaluations have not yet traced the routes by which immunity in the gut affects inflammatory arthritis. To characterize the community structure and associated functional processes driving gut microbial involvement in arthritis, the Inflammatory Arthritis Microbiome Consortium investigated 440 stool shotgun metagenomes comprising 221 adults diagnosed with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis and 219 healthy controls and individuals with joint pain without an underlying inflammatory cause. Diagnosis explained about 2% of gut taxonomic variability, which is comparable in magnitude to inflammatory bowel disease. We identified several candidate microbes with differential carriage patterns in patients with elevated blood markers for inflammation. Our results confirm and extend previous findings of increased carriage of typically oral and inflammatory taxa and decreased abundance and prevalence of typical gut clades, indicating that distal inflammatory conditions, as well as local conditions, correspond to alterations to the gut microbial composition. We identified several differentially encoded pathways in the gut microbiome of patients with inflammatory arthritis, including changes in vitamin B salvage and biosynthesis and enrichment of iron sequestration. Although several of these changes characteristic of inflammation could have causal roles, we hypothesize that they are mainly positive feedback responses to changes in host physiology and immune homeostasis. By connecting taxonomic alternations to functional alterations, this work expands our understanding of the shifts in the gut ecosystem that occur in response to systemic inflammation during arthritis. Editor's summary: The gut microbiome has been implicated in inflammatory conditions such as inflammatory arthritis, but a head-to-head analysis of which microbes are associated with which types of inflammatory arthritis remains to be shown. Here, Thompson et al. analyzed the microbiome of 221 individuals with rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis, as well as 219 healthy controls. The authors found taxa-level alterations that were shared across the inflammatory arthritis phenotypes and further identified microbiome-driven functional pathways that associated with inflammatory disease. Together, these data expand our understanding of how the functions of the gut microbiome may influence inflammation in humans. —Courtney Malo [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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