| Autor: |
Futterman, Laurie G., Lemberg, Louis |
| Předmět: |
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| Zdroj: |
American Journal of Critical Care; May2005, Vol. 14 Issue 3, p244-247, 4p |
| Abstrakt: |
There is incontrovertible evidence that lowering LDL with statin therapy results in clinical benefit in patients with atherosclerosis. The added significance of HDL cholesterol has surfaced following the identification of apo A-IM, a molecular variant of human apo A-I, initially found in a family living in Limone sul Garda (a small town near Milan, Italy). The carriers of apo A-IM have a markedly low HDL cholesterol level and a very low prevalence of atherosclerosis. An artificial HDLMilano developed by a recombinant formulation has been highly successful in preliminary studies. Although recombinant apo A-IM is very effective treatment for atherosclerosis, preventive measures remain primary in this potentially diffuse arterial disease: for example, diet, exercise, and maintaining a normal blood pressure and weight. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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