| Autor: |
Kaplan, Svetlana, Kaplan, Alexander, Marcoe, Karen F., Gey, George O., Schiller, Harvey, Roby, Paul V., Fisher, Lloyd D., El-Massry, Sherif, Sauvage, Lester R. |
| Předmět: |
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| Zdroj: |
Clinical & Applied Thrombosis/Hemostasis; Spring1995, Vol. 1 Issue 2, p135-141, 7p, 3 Charts, 5 Graphs |
| Abstrakt: |
We describe a new method of interpreting platelet aggregometry results and its correlation to platelet secretory protein levels. We studied 123 healthy male volunteers, 37-85 years of age. The aggregation response to 2.5 µM ADP was measured in a standardized platelet suspension (SPS) prepared from platelet-rich plasma. Turbidimetric measurements included amplitude of the primary aggregation wave (Amp1), maximum aggregation amplitude (Amax), and area under the aggregation curve (Sagg). A platelet aggregation (PA) score was calculated as (Amp1/Amax) · Sagg · (whole-blood platelet count/SPS platelet count). β-Thromboglobulin (β-TG) and platelet factor 4 (PF4) levels were measured by radioimmunoassay. The PA score correlated significantly (p < 0.0001) with β-TG (r- = 0.86) and PF4 (r = 0.87). It was concluded that the PA score correlates closely with individ-ual subjects' propensities to platelet activation, as reflected by plasma β-TG and PF4 levels. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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