Association analysis of the -308G > A promoter polymorphism of the tumor necrosis factor alpha (TNF-α) gene in Japanese patients with schizophrenia.

Autor:	Hashimoto, R., Yoshida, M., Ozaki, N., Yamanouchi, Y., Iwata, N., Suzuki, T., Kitajima, T., Tatsumi, M., Kamijima, K., Kunugi, H.
Předmět:	SCHIZOPHRENIA GENETIC polymorphisms GENES TUMOR necrosis factors PSYCHOSES POPULATION genetics
Zdroj:	Journal of Neural Transmission; Feb2004, Vol. 111 Issue 2, p217-221, 5p
Abstrakt:	Summary. Two research groups have thus far reported a significant association between schizophrenia and a promoter polymorphism (-308G > A) of the gene encoding tumor necrosis factor alpha (TNF-α), while contradictive negative results have also been reported. We examined the possible association in a Japanese sample of 297 schizophrenia cases and 458 controls. Allele frequencies of both the patients and controls were very low (1.5% and 0.8%, respectively), and the difference was not statistically significant. We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-α gene. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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