Home-based therapy with ready-to-use therapeutic food is of benefit to malnourished, HIV-infected Malawian children.

Autor:	Ndekha, M. J., Manary, M. J., Ashorn, P., Briend, A.
Předmět:	HIV infections BODY weight DRUGS DRUG therapy JUVENILE diseases HIV infection complications ANTHROPOMETRY CLINICAL trials COMPARATIVE studies ELEMENTAL diet LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NUTRITION disorders in children NUTRITION disorders in infants REGRESSION analysis RESEARCH EVALUATION research RANDOMIZED controlled trials BLIND experiment
Zdroj:	Acta Paediatrica; Feb2005, Vol. 94 Issue 2, p222-225, 4p
Abstrakt:	Aim: To determine if home-based nutritional therapy will benefit a significant fraction of malnourished, HIV-infected Malawian children, and to determine if ready-to-use therapeutic food (RUTF) is more effective in home-based nutritional therapy than traditional foods.Methods: 93 HIV-positive children >1 y old discharged from the nutrition unit in Blantyre, Malawi were systematically allocated to one of three dietary regimens: RUTF, RUTF supplement or blended maize/soy flour. RUTF and maize/soy flour provided 730 kJ x kg(-1) x d(-1), while the RUTF supplement provided a fixed amount of energy, 2100 kJ/d. These children did not receive antiretroviral chemotherapy. Children were followed fortnightly. Children completed the study when they reached 100% weight-for-height, relapsed or died. Outcomes were compared using regression modeling to account for differences in the severity of malnutrition between the dietary groups.Results: 52/93 (56%) of all children reached 100% weight-for-height. Regression modeling found that the children receiving RUTF gained weight more rapidly and were more likely to reach 100% weight-for-height than the other two dietary groups (p < 0.05).Conclusion: More than half of malnourished, HIV-infected children not receiving antiretroviral chemotherapy benefit from home-based nutritional rehabilitation. Home-based therapy RUTF is associated with more rapid weight gain and a higher likelihood of reaching 100% weight-for-height. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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