Fluid resuscitation with colloids of different molecular weight in septic shock.
Autor: | Molnár, Zsolt, Mikor, András, Leiner, Tamás, Szakmány, Tamás, Molnár, Zsolt, Mikor, András, Leiner, Tamás, Szakmány, Tamás |
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Předmět: |
SEPTIC shock
BACTERIAL disease complications COLLOIDS MOLECULAR weights CLINICAL medicine MEDICAL research THERAPEUTIC use of proteins ADULT respiratory distress syndrome treatment SEPTIC shock treatment HYDROXYETHYL starch PHARMACEUTICAL gels PHYSICAL & theoretical chemistry CLINICAL trials COMPARATIVE studies FLUID therapy HEMODYNAMICS LONGITUDINAL method RESEARCH methodology MEDICAL cooperation MENTAL health surveys OXYGEN therapy RESEARCH ADULT respiratory distress syndrome RESUSCITATION EVALUATION research RANDOMIZED controlled trials TREATMENT effectiveness DISEASE complications THERAPEUTICS |
Zdroj: | Intensive Care Medicine; Jul2004, Vol. 30 Issue 7, p1356-1360, 5p |
Abstrakt: | Objective. The aim of this study was to investigate the short-term effect of fluid resuscitation with 4% modified fluid gelatine (GEL) versus 6% hydroxyethyl starch (HES) on haemodynamics and oxygenation in patients with septic shock and acute lung injury (ALI). Design. Prospective randomised clinical trial. Setting. Twenty-bed intensive care unit in a university hospital. Patients. Thirty hypovolemic patients (intrathoracic blood volume index, ITBVI <850 ml/m2) in septic shock with ALI were randomised into HES (mean molecular weight: 200,000 Dalton, degree of substitution 0.6) and GEL (mean molecular weight: 30,000 Dalton) groups (15 patients each). Interventions. For fluid resuscitation 250 ml/15 min boluses (max. 1,000 ml) were given until the end point of ITBVI >900 ml/m2 was reached. Repeated haemodynamic measurements were done at baseline (t |
Databáze: | Complementary Index |
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