Protein losing enteropathy in critically ill adult patients with burns: a preliminary report.

Autor:	Venkatesh, Balasubramanian, Gough, Jenny, Ralston, David R., Muller, Michael, Pegg, Stuart
Předmět:	PROTEIN-losing enteropathy RESUSCITATION GASTROINTESTINAL system BLOOD proteins ALBUMINS FECES BURNS & scalds complications TREATMENT for burns & scalds INTESTINAL disease diagnosis ALPHA 1-antitrypsin BURNS & scalds CATASTROPHIC illness COMPARATIVE studies FLUID therapy INTESTINAL diseases LONGITUDINAL method RESEARCH methodology MEDICAL cooperation NUTRITIONAL assessment REGRESSION analysis RESEARCH SERUM albumin TIME EVALUATION research SEVERITY of illness index
Zdroj:	Intensive Care Medicine; Jan2004, Vol. 30 Issue 1, p162-166, 5p
Abstrakt:	Objective: Few data have been published regarding protein losing enteropathy in adult patients with burns. This study characterised the presence of protein-losing enteropathy in adults with burns and examined the relationship between the magnitude of burn size and the severity of protein loss.Methods: Twenty adult patients with burns (BSA 31+/-25%, range 2-80%) were studied. Fluid resuscitation was based on the Parkland's formula. Protein loss into the gastrointestinal tract was measured using faecal alpha1-antitrypsin (FA-1-AT) concentrations. Serial measurements of serum protein and albumin concentrations were performed.Results: Fourteen patients demonstrated elevations in FA-1-AT levels. The mean peak FA-1-AT level was 3.6+/-4.2 mg/g dry weight of stool. Two patients demonstrated elevated FA-1-AT excretion 1.5 months and 3 months after the burns. There was a good correlation between burn size and FA-1-AT excretion (R2=0.40).Conclusions: Protein losing enteropathy was demonstrable in patients with major burns. The magnitude of this phenomenon appears to be proportional to the burns size. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Full text from SpringerLink