Synthesis of Some Halogen- and Nitro-substituted Nicotinic Acids and Their Fragmentation Under Electron Impact.

Autor: Dyadyuchenko, L. V., Strelkov, V. D., Mikhailichenko, S. N., Zaplishny, V. N.
Předmět:
Zdroj: Chemistry of Heterocyclic Compounds; Mar2004, Vol. 40 Issue 3, p308-314, 7p
Abstrakt: Features of electrophilic and nucleophilic substitution under chlorination and nitration reactions conditions have been investigated for 6-hydroxy- and 6-methyl-substituted derivatives of 3-cyano-4-methyl-2(1H)-pyridones. The polychloro- and nitro-substituted 3-cyano-4-methylpyridines obtained were used as synthons in the synthesis of some polyhalo- and nitro-substituted nicotinic acids and their amides. The fragmentation pathways of the synthesized compounds under electron impact have been studied. [ABSTRACT FROM AUTHOR]
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