| Autor: |
Parker, J. Alex, Arango, Margarita, Abderrahmane, Salima, Lambert, Emmanuel, Tourette, Cendrine, Catoire, Hélène, Néri, Christian |
| Předmět: |
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| Zdroj: |
Nature Genetics; Apr2005, Vol. 37 Issue 4, p349-350, 2p |
| Abstrakt: |
We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal dysfunction phenotypes induced by mutant polyglutamines in transgenic Caenorhabditis elegans. These effects are dependent on daf-16 (Forkhead). Additionally, resveratrol rescued mutant polyglutamine-specific cell death in neuronal cells derived from HdhQ111 knock-in mice. We conclude that Sir2 activation may protect against mutant polyglutamines. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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