| Autor: |
Ecker, Jerome A., Doane, Wilton A., Dickson, Delbert R. |
| Předmět: |
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| Zdroj: |
American Journal of Gastroenterology (Springer Nature); Feb1961, Vol. 35 Issue 2, p127-137, 11p |
| Abstrakt: |
The subject of diffuse familial polyposis of the colon has been reviewed. It is an uncommon heredofamilial disease, transmitted by and to males and females as a mendelian dominant characteristic. Usually, hundreds of polyps occur at puberty, originally benign; but the eventual transition to malignancy is so common that polyposis is always a malignant disease. It is most important that all family relatives be examined thoroughly and repeatedly. Bloody stools and diarrhea are sometimes observed, but the disease may be silent and asymptomatic. Proctosigmoidoscopic examinations and x-rays of the colon with double contrast methods are necesary for confirmation of the diagnosis, with surgical biopsy of the polyps. Most sufferers with untreated familial polyposis will have inoperable cancer of the colon or will be dead at 50 without surgery. Subtotal colectomy and ileoproctostomy with periodic and careful fulguration of recurring adenomas in the remaining rectal stump offer relative safety and preservation of normal bowel habits in most patients with diffuse familial polyposis. Marked involvement of the rectum or an uncooperative patient can be a reason for complete colectomy and permanent ileostomy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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