| Autor: |
QIN Hai-long, YAO Jia-hui, WANG Yan, XU Qi-peng, LIU Zheng, LI You-bin, GONG Jing-wen |
| Předmět: |
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| Zdroj: |
Journal of Hainan Medical University; Apr2023, Vol. 29 Issue 7, p1-7, 7p |
| Abstrakt: |
Objective: To explore the anti-diabetic effects and its underlying mechanism of Annona muricata Linn fruit ethanol extract (AME). Methods: Streptozotocin-induced type 2 diabetic (T2DM) mouse model was constructed. Those diabetic mice were randomly grouped and given 50 mg/kg acarbose or AME (200 mg/kg, 100 mg/kg or 50 mg/kg) for four weeks. The body weight, postprandial blood glucose and glycosylated hemoglobin levels were measured during the administration. After the administration, a glucose tolerance test was performed, and the levels of triglycerides, cholesterol and low-density lipoproteins in mice were detected by biochemical test kits. The inhibitory activity of AME on α-glucosidase in vivo and in vitro was determined by enzyme inhibition tests. Results: AME significantly reduced weight gain, postprandial blood glucose, glycosylated hemoglobin and low-density lipoprotein levels in T2DM mice; enhanced glucose tolerance and pancreatic β-cell function of T2DM mice; inhibited α-glucosidase activity in mouse intestine in an noncompetitive manner. Conclusion: AME may noncompetitive inhibit α-glucosidase activity and reduce postprandial glucose intake to achieve a therapeutic and regulatory effect on type 2 diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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