| Abstrakt: |
Reaction of thiosemicarbazide with carbondisulfide in the presence of sodium carbonate and absolute ethyl alcohol afforded compound 2-amino-5-mercapto-1,3,4-thiadiazole (1). Compound (1) was converted to analogues diazonium chloride through reaction with nitrous acid which is coupled with phenoxide salt of 2-hydroxybenzaldehyde to yield the azoaldehyde (2). Compound (2) was reacted with several substituted phenyl amines (2-aminophenol, 3-aminophenol, 4-aminophenol, 2-nitroaniline, 3-nitroaniline, 4-nitroaniline and 2-chloroaniline), respectively via microwave irradiation method to produce the imine compounds (3a-g). The intermediate compounds (3a-g) were reacted with α-chloroacetyl chloride in small amount of dimethylformamide as solvent by microwave irradiation to give the β-lactam compounds (4a-g). The structures of all prepared compounds were proven by (IR), (1H NMR) and (CHNS) elemental techniques. [ABSTRACT FROM AUTHOR] |
