| Autor: |
Rogers, Thomas F., Goodwin, Eileen C., Briney, Bryan, Sok, Devin, Beutler, Nathan, Strubel, Alexander, Nedellec, Rebecca, Khoa Le, Brown, Michael E., Burton, Dennis R., Walker, Laura M. |
| Zdroj: |
Science Immunology; 2017, Vol. 2 Issue 14, p1-12, 12p, 3 Diagrams, 2 Graphs |
| Abstrakt: |
Zika virus (ZIKV) shares a high degree of homology with dengue virus (DENV), suggesting that preexisting immunity to DENV could affect immune responses to ZIKV. We have tracked the evolution of ZIKV-induced B cell responses in three DENV-experienced donors. The acute antibody (plasmablast) responses were characterized by relatively high somatic hypermutation and a bias toward DENV binding and neutralization, implying the early activation of DENV clones. A DENV-naïve donor in contrast showed a classical primary plasmablast response. Five months after infection, the DENV-experienced donors developed potent type-specific ZIKV neutralizing antibody responses in addition to DENV cross-reactive responses. Because cross-reactive responses were poorly neutralizing and associated with enhanced ZIKV infection in vitro, preexisting DENV immunity could negatively affect protective antibody responses to ZIKV. The observed effects are epitope-dependent, suggesting that a ZIKV vaccine should be carefully designed for DENV-seropositive populations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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