Comparison of Commercial Low Molecular Weight Heparin and Homemade Anti-Xa Calibrators to a Commercial Specific Anti-Xa Calibrator for Plasma Rivaroxaban Quantification by Anti-Xa Oral Anticoagulant Plasma Concentration Chromogenic Assay.
| Autor: | Divsalar, Bita, Kalantari, Tahereh, Mohebbi, Soheila, Bahmanimehr, Ardeshir, Shahsavani, Amin, Borhani-Haghighi, Afshin |
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| Předmět: |
BIOLOGICAL assay equipment
BLOOD testing ENOXAPARIN CLINICAL pathology RELIABILITY (Personality trait) BLOOD coagulation tests PREDICTIVE tests CONFIDENCE intervals CALIBRATION ANTICOAGULANTS REGRESSION analysis NIH Stroke Scale RIVAROXABAN COMPARATIVE studies PEARSON correlation (Statistics) LOW-molecular-weight heparin COMMERCIAL product evaluation STROKE patients DESCRIPTIVE statistics INTRACLASS correlation RESEARCH funding COLLECTION & preservation of biological specimens SENSITIVITY & specificity (Statistics) RECEIVER operating characteristic curves DATA analysis software PHARMACODYNAMICS |
| Zdroj: | Laboratory Medicine; Jul2023, Vol. 54 Issue 4, p400-405, 6p |
| Abstrakt: | Objective The main concern about measuring the concentration of rivaroxaban by anti-Xa assay in some laboratories is the lack of a commercial specific calibrator in emergencies. Therefore, this study aimed at providing a homemade anti-Xa calibrator and commercial low molecular weight heparin (LMWH) anti-Xa calibrator. Methods The anti-Xa plasma concentration of rivaroxaban was measured in 70 patients using a commercial specific anti-Xa calibrator, a commercial LMWH anti-Xa calibrator, and a homemade anti-Xa calibrator. Results We demonstrated a significant correlation and agreement (P < .001) between LMWH-calibrated anti-Xa and the commercial specific calibrator. A significant correlation (P < .001) was found between homemade calibrated anti-Xa made by normal pooled plasma and that calibrated with a commercial specific drug. The nonspecific homemade and LMWH calibrators had excellent agreement (P < .001) and can be used interchangeably. Conclusion Our data showed that for estimating rivaroxaban concentrations, the LMWH calibrator could be used as an alternative calibrator in the anti-Xa assay. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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