| Autor: |
Ocmant, Annick, Roisin, Sandrine, Mathieu, Delphine, Brauner, Jonathan, De Leener, Frédéric |
| Předmět: |
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| Zdroj: |
Laboratory Medicine; Jul2023, Vol. 54 Issue 4, p388-391, 4p |
| Abstrakt: |
Objective Patients and physicians are increasingly requesting their clinical laboratory to provide SARS-CoV-2 serology interpretation. Our study aimed to assess the evolution of SARS-CoV-2 antibodies in Moderna-vaccinated health care workers. Methods We analyzed the evolution of mRNA-1273 (Moderna)–elicited antibodies by 2 high-throughput assays, TrimericS IgG (Diasorin) and SARS-CoV-2 IgG-II (Abbott). Results After the first injection, the COVID-19–recovered vaccinees showed a serological response as strong as that observed 1 month after the second injection in participants without COVID-19 history. Although remaining above the positivity thresholds, the TrimericS immunoglobulin G (IgG) and anti-RBD (receptor-binding domain) IgG levels fell considerably between 1 and 7 months postvaccination, dropping to 10.6% and 13% for the COVID-19 recovered subgroup and to 11.7% and 9.3% for the COVID-19 naive subgroup. Conclusion Regardless of the test used, a decrease in circulating anti-SARS-CoV-2 IgG levels should be expected a few months after vaccination. As this decline does not preclude the efficacy of immune response, caution is necessary when interpretating postvaccination serological data. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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