Front Cover: Allosteric Tuning of Caspase‐7: Establishing the Nexus of Structure and Catalytic Power (Chem. Eur. J. 40/2023).

Autor:	Hobbs, Kathryn F., Propp, Jonah, Vance, Nicholas R., Kalenkiewicz, Andrew, Witkin, Katie R., Ashley Spies, M.
Předmět:	CASPASES DRUG discovery STRUCTURE-activity relationships
Zdroj:	Chemistry - A European Journal; 7/14/2023, Vol. 29 Issue 40, p1-1, 1p
Abstrakt:	Our insights from exploration of caspase-7 allostery offer a new path for navigating allosteric drug discovery. Allostery, caspases, drug discovery, enzyme catalysis Keywords: allostery; caspases; drug discovery; enzyme catalysis EN allostery caspases drug discovery enzyme catalysis 1 1 1 07/19/23 20230714 NES 230714 B Mapping the constellation of structural and dynamic changes b concurrent with allosteric inhibitor binding to caspase-7, also known as allosteric structure-activity relationships (ASARs), reveals the nexus between the active site and the remote allosteric pocket. [Extracted from the article]
Databáze:	Complementary Index
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