Age Related Changes in Indices of Bone Metabolism and Oxidative Stress in Postmenopausal Women in Southern Nigeria.
Autor: | Nsonwu-Anyanwu, Augusta Chinyere, Eworo, Raymond Ekong, Nsonwu, Magnus Chinonye, Akpan, Uwem Okon, Kalu, Faith Adamma, Nwevo, Eberechi Ogbonna |
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Předmět: |
BONE metabolism
DISEASE complications GLUTATHIONE HOMEOSTASIS RESEARCH AGE distribution CROSS-sectional method ESTROGEN OXIDATIVE stress MALONDIALDEHYDE RISK assessment COMPARATIVE studies T-test (Statistics) POSTMENOPAUSE AGING ENZYME-linked immunosorbent assay OSTEOARTHRITIS QUESTIONNAIRES DESCRIPTIVE statistics MENOPAUSE NITRIC oxide CALCIUM BODY mass index SOCIODEMOGRAPHIC factors STATISTICAL correlation DATA analysis software WOMEN'S health DISEASE risk factors |
Zdroj: | Journal of Advances in Medical & Biomedical Research; Mar/Apr2023, Vol. 31 Issue 145, p125-132, 8p |
Abstrakt: | Background & Objective: Oxidative stress (OS) associated with estrogen deficiency in menopause has been implicated in various complications of menopause. Some indices of OS, bone metabolism and uric acid (UA) in postmenopausal women were assessed as possible predictors of gouty osteoarthritis. Materials & Methods: This case-control study enrolled 40 postmenopausal women and 60 premenopausal women as participants. The levels of reduced glutathione (GSH), nitric oxide (NO), total plasma peroxides (TPP), total antioxidant capacity (TAC), malondialdehyde (MDA), inorganic phosphate (Pi), total calcium (tCa) and UA were estimated by colorimetry, estradiol (E2) by ELISA and oxidative stress index (OSI) by calculation. Data were analyzed using t-test, correlation and regression at P<0.05. Results: Postmenopausal women had higher UA, OSI and lipid peroxidation (higher MDA, TPP) with lower E |
Databáze: | Complementary Index |
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