| Abstrakt: |
In one aspect of the present invention, the wild type aroG gene is replaced by a modified aroG gene which codes for an AroG protein that is resistant to feedback inhibition by one or more metabolites of the aromatic amino acid pathway within the microbial cell. Keywords: Adipic Acids; Amino Acids; Anions; Aromatic Amino Acids; Bioengineering; Business; Cyclic Amino Acids; Dicarboxylic Acids; Engineering; Enzymes and Coenzymes; Genetic Engineering; Genetics; Health and Medicine; Patents; Peptides; Phosphates; Phosphoric Acids; Proteins; Ptt Global Chemical Public Company Limited; Synthase; Technology EN Adipic Acids Amino Acids Anions Aromatic Amino Acids Bioengineering Business Cyclic Amino Acids Dicarboxylic Acids Engineering Enzymes and Coenzymes Genetic Engineering Genetics Health and Medicine Patents Peptides Phosphates Phosphoric Acids Proteins Ptt Global Chemical Public Company Limited Synthase Technology 2744 2744 1 07/17/23 20230721 NES 230721 2023 JUL 21 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- A patent by the inventors Hermann, Theron (Arlington, MA, US), Sillers, Ryan (Reading, MA, US), Spencer, Michelle (Woburn, MA, US), Udani, Russell (Arlington, MA, US), Yocum, R. Rogers (Lexington, MA, US), filed on May 21, 2021, was published online on June 27, 2023, according to news reporting originating from Alexandria, Virginia, by NewsRx correspondents. A recent United States Patent Application Publication No. US2015/0044755, which is incorporated herein by reference in its entirety, provides improved biocatalysts for muconic acid production involving constitutive expression of relevant gene, improved heterologous genes and novel "leaky" AroE enzymes. [Extracted from the article] |
