Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome.

Autor:	Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P., Launonen, V., Näätsaari, L, Mäkelä, T P
Předmět:	GENETIC mutation CHROMOSOME abnormalities GENES PROTEINS BIOMOLECULES DISEASES CARRIER proteins COMPARATIVE studies ENZYMES GENETIC polymorphisms RESEARCH methodology MEDICAL cooperation MEMBRANE proteins PEUTZ-Jeghers syndrome RESEARCH TRANSCRIPTION factors EVALUATION research NUCLEAR proteins
Zdroj:	British Journal of Cancer; 3/28/2005, Vol. 92 Issue 6, p1126-1129, 4p
Abstrakt:	Mutations in LKB1 lead to Peutz-Jeghers syndrome (PJS). However, only a subset of PJS patients harbours LKB1 mutations. We performed a mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in 28 LKB1-negative PJS patients. No disease-causing mutations were detected in the studied genes in PJS patients from different European populations. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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