| Autor: |
Höck, Michaela, Sappler, Maria, Hammerl, Marlene, Griesmaier, Elke, Ndayisaba, Jean‐Pierre, Schreiner, Christina, Pupp‐Peglow, Ulrike, Kiechl‐Kohlendorfer, Ursula, Neubauer, Vera |
| Předmět: |
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| Zdroj: |
Acta Paediatrica; Aug2023, Vol. 112 Issue 8, p1706-1714, 9p |
| Abstrakt: |
Aim: To investigate the direct effect of prophylactic low‐dose paracetamol administration for ductal closure on neurodevelopmental outcome in very preterm infants who did not receive ibuprofen or surgical ligation for treatment of a patent ductus arteriosus. Methods: Infants < 32 gestational weeks born 10/2014–12/2018 received prophylactic paracetamol (paracetamol group, n = 216); infants born 02/2011–09/2014 did not receive prophylactic paracetamol (control group, n = 129). Psychomotor (PDI) and mental (MDI) outcome were assessed using Bayley Scales of Infant Development at 12 and 24 months corrected age. Results: Our analyses showed significant differences in PDI and MDI at age 12 months (B = 7.8 (95% CI 3.90–11.63), p < 0.001 and B = 4.2 (95% CI 0.81–7.63), p = 0.016). At age 12 months, the rate of psychomotor delay was lower in the paracetamol group (OR 2.22, 95% CI 1.28–3.94, p = 0.004). There was no significant difference between the rates of mental delay at any time‐point. All group differences remained significant after adjustment for potential confounders (PDI 12 months B = 7.8 (95% CI 3.77–11.34), p < 0.001, MDI 12 months B = 4.3 (95% CI 0.79–7.45), p = 0.013, PDI < 85 12 months OR 2.65 (95% CI 1.44–4.87), p = 0.002). Conclusion: We found no impairment of psychomotor and mental outcome at age 12 and 24 months in very preterm infants after prophylactic low‐dose paracetamol administration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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