| Autor: |
McKenna, Marshall, Epperla, Narendranath, Ghobadi, Armin, Liu, Jieqi, Lazaryan, Aleksandr, Ibrahim, Uroosa, Jacobson, Caron A., Naik, Seema G., Nastoupil, Loretta, Chowdhury, Sayan Mullick, Voorhees, Timothy J., Jacobs, Miriam T., Farooq, Umar, Osman, Keren, Olszewski, Adam J., Ahmed, Sairah, Evens, Andrew M. |
| Předmět: |
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| Zdroj: |
British Journal of Haematology; Jul2023, Vol. 202 Issue 2, p248-255, 8p |
| Abstrakt: |
Summary: The use of CD19 chimeric antigen receptor T‐cell (CAR‐T) therapy for relapsed/refractory solid organ transplantation (SOT)‐related post‐transplant lymphoproliferative disorder (PTLD) is not well studied. We conducted a multicentre, retrospective analysis of adults with relapsed/refractory SOT‐associated PTLD. Among 22 relapsed/refractory SOT‐PTLD patients, the pathology was monomorphic B cell. Prior SOTs included 14 kidney (64%), three liver (14%), two heart (9%), one intestinal (5%), one lung (5%), and one pancreas after kidney transplant (5%). The median time from SOT to PTLD diagnosis was 107 months. Pre‐CAR‐T bridging therapy was used in 55% of patients, and immunosuppression was stopped completely before CAR‐T infusion in 64%. Eighteen (82%) patients experienced cytokine release syndrome: one (5%) each grade (G) 3 and G4. The immune effector cell‐associated neurotoxicity syndrome was observed in 16 (73%) patients: six (27%) G3 and two (9%) G4. The overall response rate was 64% (55% complete response). Three patients (14%) experienced allograft rejection after CAR‐T. The two‐year progression‐free survival and overall survival rates were 35% and 58%, respectively. Additionally, the achievement of CR post‐CAR‐T was strongly associated with survival. Collectively, the safety and efficacy of CD19 CAR‐T therapy in relapsed/refractory SOT‐related PTLD appeared similar to pivotal CAR‐T data, including approximately one‐third of patients achieving sustained remission. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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