| Autor: |
Cruz, Vitória Maria Sousa, Pérez‐de‐Oliveira, Maria Eduarda, dos Santos Leite, Éder Gerardo, Louredo, Brendo Vinicius Rodrigues, Bezerra, Hélen Kaline Farias, Lopes, Márcio Ajudarte, Vargas, Pablo Agustin, Santos‐Silva, Alan Roger, Kowalski, Luiz Paulo, da Cruz Perez, Danyel Elias |
| Předmět: |
|
| Zdroj: |
Head & Neck; Aug2023, Vol. 45 Issue 8, p2136-2148, 13p |
| Abstrakt: |
Sialoblastoma is a rare malignant salivary gland tumor. The aim of this study was to review the available published data on sialoblastoma in a comprehensive analysis of its clinicopathologic characteristics, treatment, and outcomes. An unrestricted electronic search was performed in the following databases: MEDLINE/PubMed, EMBASE, Scopus, Web of science, and gray literature databases. Eligibility criteria included publications with sufficient clinical, imaging, and histopathological information to confirm the diagnosis of sialoblastoma. Data were evaluated descriptively and analytically. A total of 52 studies met the eligibility criteria. In total, 62 patients were evaluated. There was no gender predilection, with the parotid being the most affected primary site (n = 28; 45.2%). In the log‐rank test, there was a significant increase in disease‐associated survival in patients younger than 1 year of age (82.8% vs. 44.4%; p = 0.003), individuals with lesions in major salivary glands (79.4% vs. 38.5%; p = 0.005), patients without metastases (77.8% vs. 14.3%; p = 0.011), encapsulated lesions (85.7% vs. 0%; p < 0.0001), congenital lesions (83.3% vs. 25.0%; p < 0.0001), and lesions that do not show perineural invasion (89.5% vs. 40%; p = 0.035). Kaplan–Meier curves estimated overall survival and disease‐free survival at 5 years of 95.5% and 68.1%, respectively. In the multivariate Cox regression model, only the presence of metastasis was identified as an independent prognostic factor (hazard ratio [HR] = 9.81; p = 0.010). Although sialoblastoma presents good prognosis, the tumor has a high recurrence rate. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text