| Autor: |
Tsai, Ming‐Hsien, Chuang, Hui‐Ching, Chien, Chih‐Yen, Huang, Tai‐Lin, Lu, Hui, Su, Yan‐Ye, Yang, Chao‐Hui, Lai, Chi‐Chih, Tsai, Wen‐Ling, Lin, Yu‐Tsai, Fang, Fu‐Min |
| Předmět: |
|
| Zdroj: |
Head & Neck; Aug2023, Vol. 45 Issue 8, p2017-2027, 11p |
| Abstrakt: |
Background: The study investigates the prognostic significance of lymph node ratio (LNR) on patients with head and neck squamous cell carcinoma (HNSCC) with coexistence of multiple adverse pathological features. Methods: In total, 100 patients with coexistence of perineural invasion, lymphovascular invasion, and extranodal extension of first primary HNSCC treated with radical surgery followed by adjuvant chemoradiotherapy were enrolled. Results: The optimal LNR cut‐off value for predicting overall survival (OS) and cancer specific survival (CSS) was 7%. In Cox model, we observed that LNR ≥7% was a statistically significant unfavorable predictor of OS (HR: 2.689; 95% CI: 1.228–5.889; p = 0.013) and CSS (HR: 3.162; 95% CI: 1.234–8.102; p = 0.016). Conclusion: For HNSCC patients with coexistence of multiple adverse pathological features, LNR is an independent survival predictor. Novel intensified treatments are needed for the subgroup of patients with a high LNR. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text