| Abstrakt: |
In the present studies, polysaccharide was extracted from 6 varieties of Cyamopsis tetragonoloba L. and its potential to form hydrogel was evaluated. The hydrogel formation was not observed in Desi and Neelam 51 variety but it formed particulate matter. Parasiya 954 and Maharani 92 formed intact, sticky, and watery gel whereas Swati and Nylon 55 formed intact, dense, and sticky gel with high water absorbing and swelling property. The rheological analysis of hydrogels (C, Pr2A, Mh2A, Sw2A, & Ny2A) suggested that they had a weak, flexible network structure and behaved as dilatant shear thickening fluid. The strength of Ny2A and Sw2A was high as compared to C, Pr2A, and Mh2A. The FESEM, FTIR, and XRD analysis of drug-loaded hydrogels confirmed the formation of polymerization in intact and sticky hydrogels, porous morphology, entrapment of insulin in hydrogels, the stable structure of insulin is retained and its amorphous dispersion in hydrogels, respectively. The in vitro controlled drug release was evaluated from each hydrogel by using insulin as a model drug using the Korsmeyer-Peppas model. The controlled drug (insulin) release was observed in formulations C, Pr2A, Mh2A, Sw2A, Ny2A, and Mh3A whereas controlled drug release was not observed in formulations Pr3A, Sw3A, Ny3A. [ABSTRACT FROM AUTHOR] |
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