Autor: |
Balducci, Estelle, Steimlé, Thomas, Smith, Charlotte, Villarese, Patrick, Feroul, Mélanie, Payet-Bornet, Dominique, Kaltenbach, Sophie, Couronné, Lucile, Lhermitte, Ludovic, Touzart, Aurore, Dourthe, Marie-Emilie, Simonin, Mathieu, Baruchel, André, Dombret, Hervé, Ifrah, Norbert, Boissel, Nicolas, Nadel, Bertrand, Macintyre, Elizabeth, Cieslak, Agata, Asnafi, Vahid |
Předmět: |
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Zdroj: |
Molecular Cancer; 7/10/2023, Vol. 22 Issue 1, p1-6, 6p |
Abstrakt: |
The reintegration of excised signal joints resulting from human V(D)J recombination was described as a potent source of genomic instability in human lymphoid cancers. However, such molecular events have not been recurrently reported in clinical patient lymphoma/leukemia samples. Using a specifically designed NGS-capture pipeline, we here demonstrated the reintegration of T-cell receptor excision circles (TRECs) in 20/1533 (1.3%) patients with T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL). Remarkably, the reintegration of TREC recurrently targeted the tumor suppressor gene, ZFP36L2, in 17/20 samples. Thus, our data identified a new and hardly detectable mechanism of gene deregulation in lymphoid cancers providing new insights in human oncogenesis. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
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