| Autor: |
Naveen, R, Nikiphorou, Elena, Joshi, Mrudula, Sen, Parikshit, Lindblom, Julius, Agarwal, Vishwesh, Lilleker, James B, Tan, Ai Lyn, Salim, Babur, Ziade, Nelly, Velikova, Tsvetelina, Gracia-Ramos, Abraham Edgar, Kuwana, Masataka, Day, Jessica, Makol, Ashima, Distler, Oliver, Chinoy, Hector, Traboco, Lisa S, Wibowo, Suryo Anggoro Kusumo, Tehozol, Erick Adrian Zamora |
| Předmět: |
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| Zdroj: |
Rheumatology; Jul2023, Vol. 62 Issue 7, p2453-2463, 11p |
| Abstrakt: |
Objective To determine COVID-19 vaccine-related adverse events (AEs) in the seven-day post-vaccination period in patients with SLE vs autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HC). Methods Data were captured through the COVID-19 Vaccination in Autoimmune Diseases (COVAD) questionnaire (March–December 2021). Multivariable regression models accounted for age, gender, ethnicity, vaccine type and background treatment. Results Among 9462 complete respondents, 583 (6.2%) were SLE patients (mean age: 40.1 years; 94.5% females; 40.5% Asian; 42.9% Pfizer-recipients). Minor AEs were reported by 83.0% of SLE patients, major by 2.6%, hospitalization by 0.2%. AE and hospitalization frequencies were similar between patients with active and inactive SLE. Rashes were more frequent in SLE patients vs HC (OR; 95% CI: 1.2; 1.0, 1.5), chills less frequent in SLE vs AIRDs (0.6; 0.4, 0.8) and nrAIDs (0.5; 0.3, 0.8), and fatigue less frequent in SLE vs nrAIDs (0.6; 0.4, 0.9). Pfizer-recipients reported higher overall AE (2.2; 1.1, 4.2) and injection site pain (2.9; 1.6, 5.0) frequencies than recipients of other vaccines, Oxford/AstraZeneca-recipients more body ache, fever, chills (OR: 2.5, 3.0), Moderna-recipients more body ache, fever, chills, rashes (OR: 2.6, 4.3). Hospitalization frequencies were similar across vaccine types. AE frequencies were similar across treatment groups, although chills were less frequent in antimalarial users vs non-users (0.5; 0.3, 0.9). Conclusion While COVID-19 vaccination-related AEs were reported by four-fifths of SLE patients, those were mostly minor and comparable to AEs reported by healthy individuals, providing reassurance regarding COVID-19 vaccination safety in SLE. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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