Kinetics of CAR-T cells and immunological profile after tisagenlecleucel therapy.

Autor: Richert-Przygońska, Monika, Stankiewicz, Joanna, Czyżewski, Krzysztof, Dębski, Robert, Kubicka, Małgorzata, Kuryło-Rafińska, Beata, Majk, Agnieszka, 1,Łukasz Ledziński, Ewa Dembna, Marquardt, Ewa, Gągola, Katarzyna, Styczyński, Jan
Předmět:
Zdroj: Acta Haematologica Polonica; 2023, Vol. 54 Issue 3, p195-197, 3p
Abstrakt: The article reports the case of a 5-year-old girl with primary refractory ALL who was treated with CAR-T cells. The patient experienced grade I CRS and grade II ICANS, which were successfully treated with tocilizumab and dexamethasone. The article discusses the monitoring of kinetics of CAR-T cells and cytokine profile, and the role of TNF-α in the development of CRS and ICAN.
Databáze: Complementary Index