Frequency of Incidental Prostate Adenocarcinoma Detection in Patients with Radical Cystoprostatectomy for Bladder Urothelial Cancer and Research into the Need for PSA Monitoring for Local-systemic Recurrence.

Autor: Dindar, Ahmet Selçuk, Yılmaz, Yüksel, Akın, Yiğit, Köse, Osman, Görgel, Sacit Nuri, Özcan, Serkan
Předmět:
Zdroj: European Archives of Medical Research; Jun2023, Vol. 39 Issue 2, p84-88, 5p
Abstrakt: Objective: The incidental prostat adenocancer (PCa) detection rate in pathology material from radical cystoprostatectomy (RCP) has rates varying from 10% to 70% in the literature. Studies have blamed one of the causes for these different rates on the use of cross-section intervals with different widths during the investigation of prostate specimens. In this study was to research the incidental PCa frequency in patients undergoing operation and simultaneously to research the need for PSA follow-up in terms of local-systemic recurrence. Methods: The pathologies of 115 patients undergoing RCP due to bladder cancer 2011 to 2017 were retrospectively investigated. A total of 26 patients,10 patients with pathology reported as non-urothelial cancer, 5 patients who were female and 11 patients who did not attend follow-up, were excluded. Eighty nine patients were included in the postoperative follow-up. Cystectomy materials were evaluated at 3 mm intervals, and prostate materials at 6 mm intervals. In addition to the evaluation of pathology results, PSA follow-up for at least 6 months was applied to all patients. Results: In study, mean age calculated as 62.8±0.9 years. Concurrent prostate adenocarcinoma was detected in 18 (20.2%) patients. Preoperative PSA was calculated as 2.06±0.2 ng/mL. PSA follow-up was applied to all patients. PSA elevation was not observed in any patient with benign prostate pathology. PSA elevation was observed in the follow-up of the only patient in the ISUP 3 with PCa. Patients with benign and malignant prostate pathology were compared in terms of age, pre-operative PSA, bladder pathology and survey. No significant difference was found between the groups. Conclusion: In patients whose prostate pathology was reported as benign, it was observed that there was no increase in PSA even if the cancer was missed. It was thought that these patients with clinically insignificant PCa did not affect the survey in these patients who already had morbidity in terms of bladder tumor. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index