| Abstrakt: |
Ketamine is one of the earliest hypnotic substances known with anesthetic and analgesic qualities and little suppressive effect on breathing. Clinical ketamine use started in the 1970s. Its safety and capacity to elicit analgesia and anaesthesia for a brief period were advantageous to doctors. Ketamine has been used extensively in therapeutic settings. To provide insight into the many uses and to highlight the dosage, delivery mechanism, and time course of these effects, this review integrates several basic scientific, preclinical, and clinical studies on ketamine. Ketamine's most well-known dissociative anaesthetic effects are not its only effects, it also possesses analgesic, anti-inflammatory, and antidepressant properties. The drug's clinical utility was questioned by its psychodysleptic side effects. Ketamine is still used in veterinary medicine, field medicine, and specialised anaesthesia despite these undesirable side effects. A thorough literature search was conducted using Medline, Google Scholar, and PubMed. The relevant papers' complete texts were printed and read. There is also more information about the more recent applications of ketamine and its drawbacks. Since ketamine has a lengthy history of therapeutic usage in a variety of contexts around the world due to its complicated mechanisms of action, we have examined its complex pharmacological characteristics in this review and its many uses since it was first developed. Like any review, this one is constrained by publication bias and a lack of data on unfavourable research that was not published. [ABSTRACT FROM AUTHOR] |
