| Autor: |
G. J., Sachin, K., Varun, Konin, Rajiv, Bhimalli, Shilpa |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2023, Vol. 14 Issue 5, p1515-1524, 10p |
| Abstrakt: |
Lipid disorders are one of the known metabolic changes associated with chronic renal failure (CRF) The prominent features of uremic dyslipidemia are an increase in plasma triglycerides and cholesterol in nearly all lipoproteins, and a reduction in high-density lipoprotein (HDL) cholesterol. Cardiovascular disease (CVD) is a major cause of mortality in patients with chronic renal failure (CRF). One of the risk factors for cardiovascular disease is dyslipidemia as it accelerates atherosclerosis. Therefore it is essential to study uremic dyslipidemia, since optimal treatment is essential for the prevention or delay of cardiovascular complications in patients with CRF. Materials and Methods: Cases of chronic renal failure associated with cardiac diseases admitted in the medical wards from Jan 2022 to Mar 2023 Dept.of cardiology, Sri Jayadeva institute of cardiology, Kalaburagi Results: Plasma triglycerides (174±60.7 mg/dl Vs 97±17 mg/dl) and VLDL fraction (34.88± 12.15 mg/dl Vs 19.3±3.49 mg/dl) were significantly elevated in CRF patients compared to controls (p < 0.001). There was significant decrease in plasma HDL (36±5.1 Vs 48.8±10.3) in CRF patients compared to controls (p < 0.001). There was no significant difference in total cholesterol (187±43.5 Vs 185.2±24.51 mg/dl) in CRF and Controls (p >0.05). On comparing lipid profiles in CRF patients on conservative management and Hemodialysis there was significant increase in triglycerides in hemodialyis group (199.01±70 Vs 155.176±47mg/dl). Conclusion: Uremic dyslipidemia is a specific Metabolic abnormality. Excess triglycerides and VLDL fraction was observed in patients of CRF both on conservative management and hemodialysis. Further, reduced level of HDL cholesterol was also observed both in conservative and hemodialysis group of CRF patients. Dyslipidemia observed in Uremic patients may contribute to accelerated atherosclerosis and further progression of chronic renal failure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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