| Autor: |
Bekke, Rachel M A ter, Schouwer, Koen de, Conti, Sergio, Claes, Godelieve R F, Vanoevelen, Jo, Gommers, Suzanne, Enden, Apollonia T J M Helderman-van den, Brunner-LaRocca, Hans-Peter |
| Zdroj: |
European Heart Journal Case Reports; Jun2023, Vol. 7 Issue 6, p1-5, 5p |
| Abstrakt: |
Background Juvenile onset of extensive atrial electromechanical failure, including atrial standstill, is a rare disease entity that may precede ventricular cardiomyopathy. Genetic variants associated with early-onset atrioventricular (AV) cardiomyopathy are increasingly recognized. Case summary A 16-year-old patient presented with atrial brady- and tachyarrhythmias and concomitant impaired atrial electromechanical function (atrial standstill). The atrial phenotype preceded the development of a predominantly right-sided AV dilated cardiomyopathy with pronounced myocardial fibrosis. A His-bundle pacemaker was installed for high-degree AV conduction block and sinus arrest. Using familial-based whole-exome sequencing, a missense mutation and a copy number variant deletion (compound heterozygosity) of the TAF1A gene (involved in ribosomal RNA synthesis) were identified. Discussion Juvenile onset of severe atrial electromechanical failure with atrial arrhythmias should prompt deep pheno- and genotyping and calls for vigilance for downstream cardiomyopathic deterioration. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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