Implant-Based Breast Reconstruction after Risk-Reducing Mastectomy in BRCA Mutation Carriers: A Single-Center Retrospective Study.
| Autor: | Cammarata, Emanuele, Toia, Francesca, Rossi, Matteo, Cipolla, Calogero, Vieni, Salvatore, Speciale, Antonino, Cordova, Adriana |
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| Předmět: |
PERIOPERATIVE care
GENETIC mutation PAIN measurement BRCA genes MAMMAPLASTY RETROSPECTIVE studies ACQUISITION of data PATIENT satisfaction FISHER exact test BREAST implants TREATMENT effectiveness T-test (Statistics) PEARSON correlation (Statistics) MEDICAL records DESCRIPTIVE statistics MASTECTOMY DECISION making in clinical medicine BODY mass index DATA analysis software ODDS ratio BREAST tumors POSTOPERATIVE pain |
| Zdroj: | Healthcare (2227-9032); Jun2023, Vol. 11 Issue 12, p1741, 22p |
| Abstrakt: | Women with BRCA gene mutations have a higher lifetime risk of developing breast cancer. Furthermore, cancer is usually diagnosed at a younger age compared to the wild-type counterpart. Strategies for risk management include intensive surveillance or risk-reducing mastectomy. The latter provides a significant reduction of the risk of developing breast cancer, simultaneously ensuring a natural breast appearance due to the preservation of the skin envelope and the nipple-areola complex. Implant-based breast reconstruction is the most common technique after risk-reducing surgery and can be achieved with either a submuscular or a prepectoral approach, in one or multiple stages. This study analyzes the outcomes of the different reconstructive techniques through a retrospective review on 46 breasts of a consecutive, single-center case series. Data analysis was carried out with EpiInfo version 7.2. Results of this study show no significant differences in postoperative complications between two-stage tissue expander/implant reconstruction and direct-to-implant (DTI) reconstruction, with DTI having superior aesthetic outcomes, especially in the prepectoral subgroup. In our experience, the DTI prepectoral approach has proven to be a safe and less time-consuming alternative to the submuscular two-stage technique, providing a pleasant reconstructed breast and overcoming the drawbacks of subpectoral implant placement. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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