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P-01.1-08 Melanoma therapies compromise signaling processes in the vascular endothelium S. Bromberger 1, M.R. Larsen 2, K. Schossleitner 1 1 Skin & Endothelium Research Division (SERD), Department of Dermatology, Medical Univers... Melanoma and other malignancies often bear mutations in the MAPK pathway - most commonly BRAF SP V600E sp , which contributes to uncontrolled proliferation and survival of tumor cells. The disruption of communication between tumor cells and TAMs could be the base of an efficient anti-cancer strategy to prevent tumor progression. Adamecz 1, P. Bicskei 1, H. Árva 1, N. Igaz 1, É. Veres 2, A. Rónavári 3, A. Gácse... 1 Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary, 2... Tumor-associated macrophages (TAMs) - as a result of re-programming driven by tumor and other stromal cells - can create and maintain an immunosuppressive environment and promote tumor malignancy. In tumour cells, ER stress is caused by their high degree of translation and metabolism as well as the tumour microenvironment. [Extracted from the article] |
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