Study Findings on Glioblastomas Published by a Researcher at University Hospital Schleswig-Holstein [Chimeric antigen receptor (CAR) T cell-based targeting of CD317 as a novel immunotherapeutic strategy against glioblastoma].

Předmět:	CHIMERIC antigen receptors GLIOBLASTOMA multiforme UNIVERSITY hospitals BRAIN tumors IMMUNOLOGIC receptors
Zdroj:	Drug Week; 7/7/2023, p469-469, 1p
Abstrakt:	Keywords: Antigen Receptors; Biological Therapy; Biomedical Engineering; Biomedicine; Biotechnology; Cancer; Cell Therapy; Drugs and Therapies; Glioblastomas; Gliomas; Health and Medicine; Immunologic Receptors; Membrane Proteins; Oncology; Pharmaceuticals EN Antigen Receptors Biological Therapy Biomedical Engineering Biomedicine Biotechnology Cancer Cell Therapy Drugs and Therapies Glioblastomas Gliomas Health and Medicine Immunologic Receptors Membrane Proteins Oncology Pharmaceuticals 469 469 1 07/03/23 20230707 NES 230707 2023 JUL 6 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on glioblastomas have been presented. We generated CD317-specific CAR T cells and demonstrate strong anti-tumor activity against several glioma cell lines as well as primary patient-derived cells with varying CD317 expression levels in vitro. Using orthotopic glioma mouse models, we demonstrate the antigen-specific anti-tumor activity of CD317-CAR T cells, which resulted in prolonged survival and cure of a fraction of CAR T cell-treated animals.". [Extracted from the article]
Databáze:	Complementary Index
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