| Autor: |
Pan, Sheng-Wei, Feng, Jia-Yih, Wu, Lawrence Shih-Hsin, Shu, Chin-Chung, Wang, Ping-Huai, Wang, Jann-Yuan, Wang, Hao-Chien, Su, Wei-Juin, Chen, Yuh-Min, Yu, Chong-Jen |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; Jul2023, Vol. 228 Issue 1, p18-27, 10p |
| Abstrakt: |
Background Mycobacterium avium complex lung disease (MAC-LD) preferentially occurs in postmenopausal women and may have immune exhaustion involving the programmed cell death 1 (PD-1) pathway. It is still unknown whether sex-specific associations between susceptibility to MAC-LD and programmed cell death 1 gene (PDCD1) polymorphisms exist. Methods Adult patients with MAC-LD (n = 152) and controls (n = 167) were included at 2 medical centers in Taiwan. Five single-nucleotide polymorphisms in PDCD1 genes were genotyped, and their associations with MAC-LD and soluble PD-1 protein were analyzed, especially in sex subgroups. Results PDCD1 rs2227982 polymorphism was associated with increased risk of MAC-LD in women (adjusted odds ratio for AA vs AG vs GG, 2.205 [95% confidence interval, 1.108–4.389]; P =.02), and the rs10204525 TT genotype was associated with low risk in men (TT vs TC and CC, 0.396 [.176–.890]; P =.02). Compared with men with rs10204525 TT, women with rs2227982 AG and with AA had 2.7- and 5.0-fold increased risks, respectively. Soluble PD-1 levels were lower in the female subgroup with rs2227982 AG and AA than in the remainder (median level [interquartile range], 46.7 [33.7-71.5] pg/mL vs 66.2 [48.6–101.5] pg/mL; P <.001). Conclusions PDCD1 genetic polymorphisms were associated with the risk of MAC-LD in a sex-specific pattern, possibly through regulation of PD-1 expression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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