Microglia in Alzheimer's disease: pathogenesis, mechanisms, and therapeutic potentials.

Autor:	Jifei Miao, Haixia Ma, Yang Yang, Yuanpin Liao, Cui Lin, Juanxia Zheng, Muli Yu, Jiao Lan
Předmět:	ALZHEIMER'S disease treatment MEMORY ALZHEIMER'S disease GENETICS DRUG discovery PHAGOCYTOSIS PHOSPHOTRANSFERASES NEUROPLASTICITY APOPTOSIS NEUROINFLAMMATION CELLULAR signal transduction LEARNING CELLS GENES PHENOTYPES
Zdroj:	Frontiers in Aging Neuroscience; 2023, p1-35, 35p
Abstrakt:	Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein aggregation in the brain. Recent studies have revealed the critical role of microglia in AD pathogenesis. This review provides a comprehensive summary of the current understanding of microglial involvement in AD, focusing on genetic determinants, phenotypic state, phagocytic capacity, neuroinflammatory response, and impact on synaptic plasticity and neuronal regulation. Furthermore, recent developments in drug discovery targeting microglia in AD are reviewed, highlighting potential avenues for therapeutic intervention. This review emphasizes the essential role of microglia in AD and provides insights into potential treatments. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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