Assessment of the pro-arrhythmic potential of anti-arrhythmic drugs: an experimental approach.
| Autor: | Verduyn, S. Cora, van Opstal, Jurren M., Leunissen, Jet D., Vos, Marc A., Verduyn, S C, van Opstal, J M, Leunissen, J D, Vos, M A |
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| Předmět: |
DRUG side effects
ARRHYTHMIA ARRHYTHMIA treatment PHARMACODYNAMICS TACHYCARDIA HEART beat ANIMAL experimentation BIOLOGICAL models COMPARATIVE studies DOGS DRUG design CLINICAL drug trials HEART block RESEARCH methodology MEDICAL cooperation MYOCARDIAL depressants PHENYLPROPANOLAMINE RABBITS RESEARCH VENTRICULAR tachycardia EVALUATION research |
| Zdroj: | Journal of Cardiovascular Pharmacology & Therapeutics; Jan2001, Vol. 6 Issue 1, p89-97, 9p |
| Abstrakt: | The article presents information on the assessment of the pro-arrhythmic potential of anti-arrhythmic drugs. Pro-arrhythmic activity is a feared side effect of almost all antiarrhythmic drugs. One of these proarrhythmic events is the occurrence of Torsude de Poitiles (TdP) arrhythmias, a polymorphic tachycardia that may develop after use of drugs. To study the mechanisms behind TdP and to screen for pro-arrhythmogenic activity, animal models have been developed during the past 20 years both in vivo as well as in vitro. This article provides the characteristics of two of these models and compares their results using clinically relevant drugs: the melhoxaminc-sensitized anesthetized rabbit, and the anesthetized chronic complete atrioventricular block dog. |
| Databáze: | Complementary Index |
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