Effects of diltiazem and esmolol on cycle length and spontaneous conversion of atrial fibrillation.

Autor:	Sticherling, Christian, Tada, Hiroshi, Hsu, William, Bares, Anton C., Oral, Hakan, Pelosi, Frank, Knight, Bradley P., Strickberger, S. Adam, Morady, Fred
Předmět:	ATRIAL fibrillation DRUG efficacy ATRIAL arrhythmias HEART diseases HEART beat ARRHYTHMIA PHARMACODYNAMICS BLOOD pressure CALCIUM antagonists CLINICAL trials COMPARATIVE studies RESEARCH methodology MEDICAL cooperation PROPANOLAMINES RESEARCH TIME EVALUATION research RANDOMIZED controlled trials DILTIAZEM THERAPEUTICS
Zdroj:	Journal of Cardiovascular Pharmacology & Therapeutics; Apr2002, Vol. 7 Issue 2, p81-88, 8p
Abstrakt:	Background: Calcium channel blocking agents have been shown to prolong the duration of atrial fibrillation. This study compared the effects of intravenous diltiazem and esmolol on the cycle length and conversion rate of pacing-induced atrial fibrillation.Methods and Results: In 41 adults without structural heart disease, atrial fibrillation was induced by rapid atrial pacing. After 3 minutes, either diltiazem (n = 13), esmolol (n = 15), or saline (n = 13) was infused. In the diltiazem group, the atrial fibrillation cycle length shortened by a mean of 43 milliseconds and became significantly shorter than in the control group, while the atrial fibrillation cycle length in the esmolol group did not change. Spontaneous termination of atrial fibrillation occurred significantly less often in the diltiazem group (23%) than in the esmolol (67%, P < 0.05) or placebo groups (77%, P = 0.01).Conclusions: Intravenous diltiazem shortens the atrial fibrillation cycle length and lowers the probability of spontaneous conversion of recent-onset atrial fibrillation to sinus rhythm. These results suggest that the use of diltiazem for acute rate control may unwittingly prolong the duration of recent-onset atrial fibrillation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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