| Autor: |
Kurita, Yusuke, Suzuki, Ko, Yagi, Shin, Hasegawa, Sho, Sato, Takamitsu, Hosono, Kunihiro, Kobayashi, Noritoshi, Endo, Itaru, Kubota, Kensuke, Nakajima, Atsushi |
| Zdroj: |
Journal of Hepato -- Biliary -- Pancreatic Sciences; Jun2023, Vol. 30 Issue 6, p777-783, 7p |
| Abstrakt: |
Background/Purpose: This study aimed to investigate the efficacy of intensive fluid‐loading therapy post‐endoscopic retrograde cholangiopancreatography (ERCP) for the prevention of post‐ERCP pancreatitis (PEP) in at‐risk patients. Methods: In this retrospective study, data of 1200 patients at risk for PEP were investigated. After propensity score matching, 404 patients were included in the normal (n = 202) and hydration (n = 202) groups. On the day of ERCP, patients in both groups were infused with 2000 ml/24 h of fluid before ERCP. Meanwhile, the hydration group received an additional 1000 ml/10 h of lactated Ringer's solution postoperatively. Results: The incidence of PEP was lower in the hydration group (12.4%) than in the normal group (24.3%) (odds ratio [OR]: 0.44; 95% CI: 0.26–0.75, p =.003). The incidence of severe PEP was 2.0% and 6.9% in the hydration and normal groups (OR: 0.27; 95% CI: 0.09–0.84, p =.027), respectively. The incidence of fatal PEP was 0% and 2.0% in the hydration and normal groups (OR: N.A.: p =.123), respectively. Conclusions: Post‐ERCP hydration may be an effective method of preventing PEP, including severe PEP, in at‐risk patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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