| Autor: |
Rakhimova, M. B., Esanov, R. S., Merzlyak, P. G., Gafurov, M. B., Kurbannazarova, R. Sh., Matchanov, O. D., Sabirov, R. Z. |
| Zdroj: |
Bulletin of Experimental Biology & Medicine; May2023, Vol. 175 Issue 1, p27-31, 5p |
| Abstrakt: |
We studied the effects of glycyrrhetinic acid (bioactive aglycone of glycyrrhizin) and its ester derivatives at positions C-3 and C-30 on the cell volume regulation in rat thymocytes under conditions of hypoosmotic stress. Native glycyrrhetinic acid completely suppressed this process with half-maximal concentration of 12.7±1.4 μM and Hill coefficient of 3.1±0.6. Formation of esters at C-3 (esters with the acetic, cinnamic and methoxi-cinnamic acid) and at C-30 (methyl ester) drastically decreased the inhibitory activity of the molecule, suggesting that intact hydroxyl group at C-3 and carboxyl group at C-30 are structurally important determinants of biological activity of glycyrrhetinic acid towards volume regulation of thymic lymphocytes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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