Giant-Cell Aortitis-Induced Acute Aortic Insufficiency: An Underestimated Etiology.

Autor: Masood Noori, Muhammad Atif, Mohammadian, Mahsa, Saeed, Hasham, Romero, Jesus, Shruti, Jesani, Fichadiya, Hardik, Elkattawy, Sherif, Jawed, Qirat, Shah, Dhaval, Shah, Kalpesh K., Loumiotis, Ioannis, Joshi, Meherwan B., Fyfe, Bille
Předmět:
Zdroj: American Journal of Case Reports; 6/22/2023, Vol. 24, p1-6, 6p
Abstrakt: Objective: Rare coexistence of disease or pathology Background: Acute aortic insufficiency can be secondary to multiple conditions, including infective endocarditis, aortic root pathologies (eg, dissection, aortitis), or traumatic injury. Aortitis involves a broad spectrum of disorders characterized by inflammatory changes in the aortic wall. This pathology can be subsequently classified depending on its etiology into inflammatory and infectious causes. Large-vessel vasculitis (giant-cell arteritis, Takayasu arteritis, and IgG4-related vasculitis) is the most common non-infectious causes of aortitis. Giant-cell aortitis usually lacks the classic clinical findings of giant-cell arteritis such as headache, visual symptoms, or jaw claudication, which can be a diagnostic challenge. However, clinicians should have a high index of suspicion, since this pathology can evolve into potentially life-threatening conditions, including aortic aneurysm, aortic wall rupture, and aortic acute dissection. Case Report: We present a case of a 76-year-old woman who presented to the Emergency Department (ED) with shortness of breath associated with orthopnea, paroxysmal nocturnal dyspnea, and mild productive cough with white sputum. A transthoracic echocardiogram demonstrated reduced left ventricular ejection fraction, dilated left ventricle, and severe aortic insufficiency. Cardiac catheterization revealed mild non-obstructive coronary arteries and severe aortic regurgitation. The surgical pathology report of the portion of the aorta was consistent with giant-cell aortitis. Conclusions: In this article, we present a case of giant-cell aortitis as an unusual etiology of acute aortic insufficiency, which is most probably under-detected in clinical practice. In addition to describing the case, we aim to highlight the importance of proper ascending aorta evaluation in patients presenting with new-onset aortic regurgitation and heart failure to prevent associated morbidity and mortality. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index