| Autor: |
Barbosa-de-Oliveira, Maria Clara, Oliveira-Melo, Paolo, Gonçalves da Silva, Marcos Henrique, Santos da Silva, Flávio, Andrade Carvalho da Silva, Felipe, Silva de Araujo, Bruno Vinicios, Franco de Oliveira, Moacir, Tadeu Correia, Aristides, Miyoshi Sakamoto, Sidnei, Valença, Samuel Santos, Lanzetti, Manuella, Schmidt, Martina, Kennedy-Feitosa, Emanuel |
| Předmět: |
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| Zdroj: |
Antioxidants; Jun2023, Vol. 12 Issue 6, p1258, 14p |
| Abstrakt: |
This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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