| Autor: |
Serrano, Davide, Bellerba, Federica, Johansson, Harriet, Macis, Debora, Aristarco, Valentina, Accornero, Chiara A., Guerrieri-Gonzaga, Aliana, Trovato, Cristina M., Zampino, Maria Giulia, Salè, Emanuela Omodeo, Bonanni, Bernardo, Gandini, Sara, Gnagnarella, Patrizia |
| Předmět: |
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| Zdroj: |
Biomedicines; Jun2023, Vol. 11 Issue 6, p1766, 12p |
| Abstrakt: |
Vitamin D and a healthy diet, based on World Cancer Research Fund (WCRF) recommendations, are considered key elements for colorectal cancer (CRC) prevention. In a CRC case-control study, we observed that CRC cases were often significantly Vitamin D deficient while subjects following WCRF recommendations significantly decreased their risk of developing CRC. We conducted a randomized phase-II trial (EudraCT number-2015-000467-14) where 74 CRC patients showed differences in response to Vitamin D supplementation, 2000 IU in average per day, according to gender and microbiota. The aim of this nested study is to correlate Vitamin D (supplementation, serum level and receptor polymorphisms), circulating biomarkers, and events (polyp/adenoma, CRC relapse and other cancers) in concomitant to WCRF recommendation adherence. Vitamin D supplementation did not modulate circulating biomarkers or follow-up events. FokI and TaqI VDR were associated with 25-hydroxyvitamin D (25OHD) levels. Patients following the WCRF recommendations had significantly lower leptin, significantly lower IL-6 (only in females), and significantly lower risk of events (HR = 0.41, 95%CI: 0.18–0.92; p = 0.03; median follow-up 2.6 years). Interestingly, no WCRF adherents had significantly more events if they were in the placebo (p < 0.0001), whereas no influence of WCRF was observed in the Vitamin D arm. While one-year Vitamin D supplementation might be too short to show significant preventive activity, a healthy diet and lifestyle should be the first step for preventive programs. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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