Relationship between galectin-3 level and disease activity in ankylosing spondylitis patients.

Autor:	Devrimsel, Gul, Arpa, Medeni, Beyazal, Munevver Serdaroglu
Předmět:	PROTEIN metabolism C-reactive protein NONPARAMETRIC statistics CELL differentiation INTERLEUKINS CYTOKINES RESEARCH evaluation ANKYLOSING spondylitis INFLAMMATION NEOVASCULARIZATION CROSS-sectional method AUTOIMMUNE diseases REGRESSION analysis RESEARCH funding BLOOD sedimentation QUESTIONNAIRES TUMOR necrosis factors DATA analysis software DISEASE exacerbation
Zdroj:	Egyptian Rheumatology & Rehabilitation; 6/22/2023, Vol. 50 Issue 1, p1-6, 6p
Abstrakt:	Background and aims: Ankylosing spondylitis (AS) is a chronic inflammatory disease that chiefly affects the sacroiliac joints and the spine. Galectin-3, a chimera-type member of the galectin family, binds glycoconjugates containing N-acetyllactosamine. Galectins play a role in regulation of embryogenesis, angiogenesis, neurogenesis, and immunity. The aim of the present study was to evaluate the serum galectin-3 level and its possible association with disease activity in AS patients. Forty five AS patients and 35 healthy controls enrolled in this study. All participants with a history of hyperlipidemia, liver, renal, hematological, familial thyroid, neoplastic, autoimmune infectious diseases and using anti-inflammatory drugs were excluded from the study. Serum galectin-3 levels concentration was measured using a commercial chemiluminescent microparticle immunoassay. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were measured. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score–CRP (ASDAS-CRP) were used to evaluate disease activity in AS patients. Results: Serum galectin-3 levels were significantly higher in AS patients compared to the control group (p = 0.04). A correlation was determined between the serum galectin-3 levels and BASDAI and ASDAS-CRP scores in the AS patients (r = 0.49, p < 0.001; r = 0.56, p < 0.001, respectively). In AS patients, serum galectin-3 levels were significantly related with CRP levels but were not related with ESR (r = 0.57, p < 0.001; r = 0.25, p = 0.09, respectively). Conclusions: The serum galectin-3 levels were higher in AS patients and were correlated with disease activity. This study may be useful to reveal the role of galectin-3 in inflammation and to evaluate disease activity in AS patients. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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