| Autor: |
Rees, Daniel, Beynon, Amy L., Lelos, Mariah J., Smith, Gaynor A., Roberts, Luke D., Phelps, Lyndsey, Dunnett, Stephen B., Morgan, Alwena H., Brown, Rowan M., Wells, Timothy, Davies, Jeffrey S. |
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| Zdroj: |
Cellular & Molecular Neurobiology; Jul2023, Vol. 43 Issue 5, p2377-2384, 8p |
| Abstrakt: |
The feeding-related hormone, acyl-ghrelin, protects dopamine neurones in murine 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-based models of experimental Parkinson's disease (PD). However, the potential protective effect of acyl-ghrelin on substantia nigra pars compacta (SNpc) dopaminergic neurones and consequent behavioural correlates in the more widely used 6-hydroxydopamine (6-OHDA) rat medial forebrain bundle (MFB) lesion model of PD are unknown. To address this question, acyl-ghrelin levels were raised directly by mini-pump infusion for 7 days prior to unilateral injection of 6-OHDA into the MFB with assessment of amphetamine-induced rotations on days 27 and 35, and immunohistochemical analysis of dopaminergic neurone survival. Whilst acyl-ghrelin treatment was insufficient to elevate food intake or body weight, it attenuated amphetamine-induced circling behaviour and SNpc dopamine neurone loss induced by 6-OHDA. These data support the notion that elevating circulating acyl-ghrelin may be a valuable approach to slow or impair progression of neurone loss in PD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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