| Autor: |
Akbar, Armaan F., Shou, Benjamin L., Feng, Cheng-Yuan, Zhao, David X., Kim, Bo Soo, Whitman, Glenn, Bush, Errol L., Cho, Sung-Min, the HERALD Investigators, Keller, Steven, Alejo, Diane, Calligy, Kate, Anderson, Scott, Menta, Arjun, Sun, Philip, Kook Kang, Jin, Rando, Hannah, Chinedozi, Ifeanyi, Hwang, Jaeho, Darby, Zachary |
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| Zdroj: |
Lung; Jun2023, Vol. 201 Issue 3, p315-320, 6p |
| Abstrakt: |
Introduction and Methods: We examined the relationship between 24-h pre- and post-cannulation arterial oxygen tension (PaO2) and arterial carbon dioxide tension (PaCO2) and subsequent acute brain injury (ABI) in patients receiving veno-venous extracorporeal membrane oxygenation (VV-ECMO) with granular arterial blood gas (ABG) data and institutional standardized neuromonitoring. Results: Eighty-nine patients underwent VV-ECMO (median age = 50, 63% male). Twenty (22%) patients experienced ABI; intracranial hemorrhage (ICH) was the most common diagnosis (n = 14, 16%). Lower post-cannulation PaO2 levels were significantly associated with ICH (66 vs. 81 mmHg, p = 0.007) and a post-cannulation PaO2 level < 70 mmHg was more frequent in these patients (71% vs. 33%, p = 0.007). PaCO2 parameters were not associated with ABI. By multivariable logistic regression, hypoxemia post-cannulation increased the odds of ICH (OR = 5.06, 95% CI:1.41–18.17; p = 0.01). Conclusion: In summary, lower oxygen tension in the 24-h post-cannulation was associated with ICH development. The precise roles of peri-cannulation ABG changes deserve further investigation, as they may influence the management of VV-ECMO patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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