| Autor: |
Jevtovic, Filip, Donghai Zheng, Houmard, Joseph A., Krassovskaia, Polina M., Lopez, Christian A., Wisseman, Breanna L., Steen, Dylan M., Broskey, Nicholas T., Isler, Christy, DeVente, Jim, Xiangming Fang, May, Linda E. |
| Zdroj: |
Journal of Clinical Endocrinology & Metabolism; Jul2023, Vol. 108 Issue 7, pe360-e370, 11p |
| Abstrakt: |
Context: Maternal exercise positively influences pregnancy outcomes and metabolic health in progeny; however, data regarding the effects of different modes of prenatal exercise on offspring metabolic phenotype is lacking. Objective: To elucidate the effects of different modes of maternal exercise on offspring umbilical cord derived mesenchymal stem cell (MSC) metabolism. Design: Randomized controlled trial. Setting: Clinical research facility. Patients: Healthy females between 18 and 35 years of age and <16 weeks' gestation. Intervention: Women were randomized to either 150 minutes of moderate intensity aerobic, resistance (RE), or combination exercise per week or to a non-exercising control. Main Outcome Measures: At delivery, MSCs were isolated from the umbilical cords. MSC glucose and fatty acid(s) metabolism was assessed using radiolabeled substrates. Results: MSCs from offspring of all the exercising women demonstrated greater partitioning of oleate (P≤0.05) and palmitate (P≤0.05) toward complete oxidation relative to non-exercisers. MSCs from offspring of all exercising mothers also had lower rates of incomplete fatty acid oxidation (P≤0.05), which was related to infant adiposity at 1 month of age. MSCs from all exercising groups exhibited higher insulin-stimulated glycogen synthesis rates (P≤0.05), with RE having the largest effect (P≤0.05). RE also had the greatest effect on MSC glucose oxidation rates (P≤0.05) and partitioning toward complete oxidation (P≤0.05). Conclusion: Our data demonstrates that maternal exercise enhances glucose and lipid metabolism of offspring MSCs. Improvements in MSC glucose metabolism seem to be the greatest with maternal RE. Clinical Trial: ClinicalTrials.gov Identifier: NCT03838146 [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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