| Abstrakt: |
INTRODUCTION/OBJECTIVES: microbiota, host barrier function, innate immunity, and the Crohn’s disease (CD) is a chronic inflammatory bowel disease of unknown aetiology. Evidence demonstrate that a person’s diet could be implicated in the pathogenesis of CD. Therefore, there is a growing interest in the use of diet as treatment or adjuvant therapy for CD. ModuLife is a dietary approach based on the Crohn’s Disease Exclusion Diet (CDED) combined with a specific Partial Enteral Nutrition (PEN) formula, that aims to reduce exposure to dietary components hypothesized to negatively affect the microbiome, innate immunity and intestinal barrier. CASE PRESENTATION: We present a case of a 34-year-male patient who was diagnosed with CD at the age of 31, after resection of 40 cm of jejunum and jejuno-jejunal anastomosis was performed due to small bowel stenoses. At that time, the patient was severely malnourished (BMI 17,4 kg/m2). After stabilization, he started with the second phase of Modulife diet in which 75% of his daily caloric and nutritional needs were met from specific foods and the other 25% from a specific PEN formula. During 6 months of ModuLife diet, patient nutritional status improved significantly (BMI 21.5 kg/m2) and he achieved clinical and biochemical remission. Currently, he is in deep remission and is still on the ModuLife diet, PEN intake is also reduced. CONCLUSION: Modulife is a promising dietary approach for inducing and maintaining remission in mild to moderate CD. Due to the restrictive nature of this diet, it is important to work with a qualified health professional to ensure that the diet meets patients nutritional and caloric needs. [ABSTRACT FROM AUTHOR] |
