| Abstrakt: |
Tumor microenvironment(TME)is a complex status of various cells, hormones, and metabolites surrounding cancer cells. Understanding the phenomenon of TME seems to be a very effective strategy for conquering cancer cells. Pancreatic cancer is a highly lethal malignancy with no current therapeutic options. Lee et al. report a novel metabolic pathway for survival of pancreatic cancer using a metabolite trancing experiment. This distinct pathway provides a new paradigm in the field of cancer therapy using tumor energy metabolism. OAT, ornithineaminotransferase; ODC, ornithine decarboxylase; SRM, spermidine synthase;SMS, spermine synthase;KLF6, Krüppel-like factor 6. [ABSTRACT FROM AUTHOR] |
